All scientific output involving the CircAdapt model is listed below.

Scientific papers
  • Walmsley J, van Everdingen W, Cramer MJ, Prinzen FW, Delhaas T, Lumens J. Combining Computer Modelling and Cardiac Imaging to Understand Right Ventricular Pump Function. Cardiovasc Res 2017;113:1486-1498. [PubMed]
  • van Everdingen WM, Walmsley J, Cramer MJ, et al. Echocardiographic Prediction of Cardiac Resynchronization Therapy Response Requires Analysis of Both Mechanical Dyssynchrony and Right Ventricular Function: A Combined Analysis of Patient Data and Computer Simulations. J Am Soc Echocardiogr 2017;30:1012-1020. [PubMed]
  • Palau-Caballero G, Walmsley J, Van Empel V, Lumens J, Delhaas T. Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model. Am J Physiol Heart Circ Physiol 2017;312:H691-H700. [PubMed]
  • Gorcsan J, Lumens J. Rocking and Flashing with Right Ventricular Pacing: Implications for Resynchronization Therapy. JACC Cardiovasc Imaging 2016;10:1100-1102. [PubMed
  • Mast TP, Teske AJ, Walmsley J, et al. Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy. J Am Coll Cardiol 2016;68:2185-2197. [PubMed]
  • Dupuis L, Lumens J, Arts T, Delhaas T. Mechano-chemical interactions in cardiac sarcomere contraction: a computational modeling study. PLoS Comput Biol 2016;12:e1005126. [PubMed]
  • Palau-Caballero G, Walmsley J, Gorcsan J, Lumens J, Delhaas T. Abnormal Ventricular and Aortic Wall Properties Can Cause Inconsistencies in Grading Aortic Regurgitation Severity: A Computer Simulation Study. J Am Soc Echocardiogr 2016;29:1122-1130. [PubMed]
  • Jones S, Lumens J, Sohaib SM, et al. BRAVO Investigators. Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function. Europace 2016;19:1178-1186. [PubMed]
  • Walmsley J, Huntjens PR, Prinzen FW, Delhaas T, Lumens J. Septal flash and septal rebound stretch have different underlying mechanisms. Am J Physiol Heart Circ Physiol 2016;310:H394-403. [PubMed]
  • Pluijmert M, Lumens J, Potse M, et al. Computer modelling for better diagnosis and therapy of patients by cardiac resynchronisation therapy. Arrhythm Electrophysiol Rev 2015;4:62–67.[PubMed]
  • Lumens J, Prinzen FW, Delhaas T. Longitudinal Strain: "Think Globally, Track Locally". JACC Cardiovasc Imaging 2015;8:1360-1363. [PubMed]
  • Lumens J, Tayal B, Walmsley J et al. Differentiating electromechanical from non-electrical substrates of mechanical discoordination to identify responders to cardiac resynchronization therapy. Circ Cardiovasc Imaging 2015;8:e003744. [PubMed]
  • Walmsley J, Arts T, Derval N et al. Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module. PLoS Comput Biol 2015;11:e1004284. [PubMed]
  • Kroon W, Lumens J, Potse M et al. In vivo electromechanical assessment of heart failure patients with prolonged QRS duration. Heart Rhythm 2015;12:1259-67. [PubMed]
  • Huntjens PR, Walmsley J, Ploux S et al. Influence of left ventricular lead position relative to scar location on response to cardiac resynchronization therapy: a model study. Europace 2014;16 Suppl 4:iv62-iv68. [PubMed]
  • Auricchio A, Lumens J, Prinzen FW. Does cardiac resynchronization therapy benefit patients with right bundle branch block: cardiac resynchronization therapy has a role in patients with right bundle branch block. Circ Arrhythm Electrophysiol 2014;7:532-542. [PubMed]
  • Kuijpers NH, Hermeling E, Lumens J et al. Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT. Am J Physiol Heart Circ Physiol 2014;306:H1644-H1659. [PubMed]
  • Lumens J. Creating your own virtual patient with CircAdapt Simulator. Eur Heart J 2014;35:335-337. [PubMed]
  • Lumens J, Ploux S, Strik M, Gorcsan J 3rd et al. Comparative electromechanical and hemodynamic effects of left ventricular and biventricular pacing in dyssynchronous heart failure: electrical resynchronization versus left-right ventricular interaction. J Am Coll Cardiol 2013;62:2395-403. [PubMed]
  • Lumens J, Leenders GE, Cramer MJ et al. Mechanistic Evaluation of Echocardiographic Dyssynchrony Indices: Patient Data Combined with Multiscale Computer Simulations. Circ Cardiovasc Imaging 2012;5:491-499. [PubMed]
  • Lumens J, Arts T, Marcus JT, Vonk-Noordegraaf A, Delhaas T. Early-diastolic left ventricular lengthening implies pulmonary hypertension-induced right ventricular decompensation. Cardiovasc Res 2012;96:286-95. [PubMed]
  • Lumens J, Delhaas T. Cardiovascular modeling in pulmonary arterial hypertension: focus on mechanisms and treatment of right heart failure using the CircAdapt model. Am J Cardiol 2012;110:39S-48S. [PubMed]
  • Arts T, Lumens J, Kroon W, Delhaas T. Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study. PLoS Comput Biol 2012;8:e1002369. [PubMed]
  • Leenders GE, Lumens J, Cramer MJ et al. Septal deformation patterns delineate mechanical dyssynchrony and regional differences in contractility: analysis of patient data using a computer model. Circ Heart Fail 2012;5:87-96. [PubMed]
  • Koeken Y, Kuijpers NH, Lumens J, Arts T, Delhaas T. Atrial septostomy benefits severe pulmonary hypertension patients by increase of left ventricular preload reserve. Am J Physiol Heart Circ Physiol 2012;302:H2654-62. [PubMed]
  • Arts T, Reesink K, Kroon W, Delhaas T. Simulation of adaptation of blood vessel geometry to flow and pressure: implications for arterio-venous impedance. Mech Res Commun 2011;42:15-21.
  • Lumens J, Blanchard DG, Arts T, Mahmud E, Delhaas T. Left ventricular underfilling and not septal bulging dominates abnormal left ventricular filling hemodynamics in chronic thromboembolic pulmonary hypertension. Am J Physiol Heart Circ Physiol 2010;299:H1083-91. [PubMed]
  • Lumens J, Arts T, Broers B et al. Right ventricular free wall pacing improves cardiac pump function in severe pulmonary arterial hypertension: a computer simulation analysis. Am J Physiol Heart Circ Physiol 2009;297:H2196-205. [PubMed]
  • Lumens J, Arts T, Delhaas T. Ventricular Mechanical Asynchrony in Pulmonary Arterial Hypertension: A Model Study. In: Ayache N, Delingette H, Sermesant M, editors. Functional Imaging and Modeling of the Heart. Nice, France: Springer Berlin / Heidelberg, 2009:249-257.
  • Lumens J, Delhaas T, Kirn B, Arts T. Three-Wall Segment (TriSeg) Model Describing Mechanics and Hemodynamics of Ventricular Interaction. Ann Biomed Eng 2009;37:2234-2255. [PubMed]
  • Lumens J, Delhaas T, Kirn B, Arts T. Modeling ventricular interaction: a multiscale approach from sarcomere mechanics to cardiovascular system hemodynamics. Pac Symp Biocomput 2008:378-89. [PubMed]
  • Kerckhoffs RC, Lumens J, Vernooy K et al. Cardiac resynchronization: insight from experimental and computational models. Prog Biophys Mol Biol 2008;97:543-61. [PubMed]
  • Arts T, Delhaas T, Bovendeerd P, Verbeek X, Prinzen FW. Adaptation to mechanical load determines shape and properties of heart and circulation: the CircAdapt model. Am J Physiol Heart Circ Physiol 2005;288:H1943-54. [PubMed]
  • Arts T, Bovendeerd P, Delhaas T, Prinzen F. Modeling the relation between cardiac pump function and myofiber mechanics. J Biomech 2003;36:731-6. [PubMed]
  • Arts T, Bovendeerd PH, Prinzen FW, Reneman RS. Relation between left ventricular cavity pressure and volume and systolic fiber stress and strain in the wall. Biophys J 1991;59:93-102. [PubMed


Book chapters
  • Arts T, Lumens J, Kroon W, Donker DW, Prinzen FW, Delhaas T. Patient-Specific Modeling of Cardiovascular Dynamics with a Major Role for Adapation. In: Kerckhoffs R, editor Patient-Specific Modeling of the Cardiovascular System: Technology-Driven Personalized Medicine. New York: Springer, 2010:21-41.